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Clinical trials, including the SURMOUNT-1 study, used 2.5 mg as the entry point to assess tolerability and minimize side effects before escalating to therapeutic doses

The medication is also not recommended for patients with severe gastrointestinal disease, including severe gastroparesis

What is the refund policy if I experience adverse effects and need to discontinue

If you are struggling to achieve HbA1c targets despite metformin and lifestyle modifications, tirzepatide offers substantial improvement potential

Weight loss typically becomes measurable by week three or four, though the initial losses often include water weight from reduced carbohydrate intake and lower insulin levels