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Documenting baseline measurements across multiple domains creates a comprehensive framework for evaluating treatment effectiveness and guides clinical decision-making regarding dose adjustments or continuation of therapy

9,10 Cardiometabolic benefits: Evidence suggests improvement in cardiometabolic risk factors, including blood pressure and lipid profiles

The subcutaneous tissue in these areas provides appropriate depth for medication depot formation, allowing for the sustained release profile necessary for once-weekly dosing

However, oral weight-loss medications do exist: oral Wegovy (semaglutide) was approved in late 2025, and Foundayo (orforglipron), an oral GLP-1 pill from Eli Lilly, was FDA-approved in April 2026

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