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A daily oral GLP-1 at a steady, lower-intensity exposure may be tolerated better for some of these patients, while still keeping them in the GLP-1 family

Both remain investigational, with no direct head-to-head comparison

Additions of either fatty acyl or polyethylene glycol (PEG) side-chains did not interfere with the relative potencies at each receptor, and provided sustained duration of action in vivo by delaying renal clearance
