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Retatrutide is an investigational injectable medication currently under clinical development for the management of obesity and type 2 diabetes

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Clinical Evidence : Clinical trials have shown Semaglutide to significantly reduce HbA1c levels and promote weight loss in adults, supporting its use in diabetes and weight management

Pharmacogenetic studies and meta-analyses support the role of polymorphisms in the SLC6A4 promoter region (5-HTTLPR) and related methylation patterns in moderating antidepressant response and risk of adverse effects, although effect sizes are modest and findings vary by ancestry and study design [25,26]