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Description
In summary, GLP-1RAs reduce ASCVD risk in individuals with T2D, and semaglutide reduces ASCVD in people with obesity, with consistent reductions in MACE observed across multiple CVOTs

Ensure you have reached therapeutic doses before concluding a medication does not work
Injection site reactions such as redness, itching, or swelling (common) can occur
Other potential contributing factors include dehydration (especially if gastrointestinal symptoms are present) and the body's adaptation period to the medication

Discussion We report a large-scale GWAS of treatment response to GLP1 medications and identify a missense variant in GLP1R , which encodes the therapeutic target of semaglutide and tirzepatide that associates with BMI loss
