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Some people experience side effects like nausea, digestive discomfort, or fatigue early on in their Tirzepatide treatment, but these issues typically subside after a few weeks

Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

S., Abernathy, M., Morford, L., Du, Y., Benson, C., Gimeno, R

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