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An analysis using five years of medical records from tens of thousands of adults diagnosed with obesity and Type 2 diabetes showed statistically significant increases of the conditions, the American Academy of Orthopedic Surgeons said in a statement

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It included a box warning regarding the risk of thyroid C-cell tumors with contraindications for patients with: A personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 Serious hypersensitivity to tirzepatide or any Zepbound excipients Monitoring is encouraged to look for symptoms of thyroid tumors, such as a lump in the neck, unexplained hoarseness, trouble swallowing, and shortness of breath