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However, sustained effectiveness is potentially plagued by lack of adherence to the drug and resumption of pre-weight loss behaviors

If you're thinking about Zepbound, the more useful question isn't which dose produces the absolute most weight loss in a trial

This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

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ATTAIN-1 Trial Highlights: - Mean weight loss of ~12.4% over 72 weeks for patients on the highest dose - Participants lost an average of 25 pounds (11.1%) regardless of trial completion - Safety profile consistent with GLP-1 class