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Indicators of oxidative stress such as lipid peroxidation have been shown to be elevated in serum from patients with bipolar disorder compared with healthy controls [204,205,206]

265 Additionally, activation of the Wnt/-catenin signaling pathway has been shown to inhibit IL-1-induced apoptosis of intestinal epithelial cells, increase the expression of ZO-1 and Occludin, improve the structure and function of the intestinal barrier, and reduce inflammatory cell infiltration