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87 Specifically, activation of Takeda G-protein-coupled receptor 5 (TGR5) by bile acids stimulates GLP-1 release from intestinal L cells

These agents have demonstrated particular promise, with semaglutide showing a 40% reduction in AD risk in subjects with T2DM compared to other GLP-1 receptor agonists in a previous cohort study [70]

The researchers asked participants: Are you currently taking or have you ever taken one of these drugs to lose weight or treat a chronic condition such as diabetes or heart disease?" Panel members were given three response options: (1) "Yes, I have taken them at least once"

The GLP-1R agonist liraglutide increases myocardial glucose oxidation rates via indirect mechanisms and mitigates experimental diabetic cardiomyopathy