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Pharmacological inhibition or genetic reduction of DPP-4 activity preserves much higher circulating levels of intact GLP-1 [191,192], and this was demonstrated to potentiate the insulinotropic effect of GLP-1 in anesthetized pigs (eventually leading to the development of DPP-4 inhibitors for clinical use) [193]

Median duration of response was not yet reached in the higher dose arm

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Curcumin targeting non-coding RNAs in colorectal cancer: therapeutic and biomarker implications

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