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allodynia from glp-1 is being reported with medications It is a heightened sensitivity to touch that can feel like pain. We are seeing it more at higher doses The important point is that Ozempic-like drugs may cause skin
Description
If reflux is the bigger issue, managing acid reflux on GLP-1 is a useful companion read

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, a class of drugs that regulate appetite, slow digestion, and help control blood sugar

The pancreas typically produces adequate digestive enzymes in patients without pancreatic insufficiency, and GLP-1 receptor agonists do not directly inhibit enzyme synthesis
Hu K, Barrett TG

However, real life application of GLP-1 nanomedicine should be performed preferably via an intravenous route, where the nanoparticles may accumulate only in the inflamed tissues through leaky vasculature by passive targeting