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OWL833, an orally active nonpeptide GLP-1 receptor agonist, improves glucose tolerance by increasing insulin secretion and reduces food intake of cynomolgus monkeys

Early clinical trials in patients with metabolic disorders suggest improvements in depressive symptoms, quality of life, and cognitive function, with some effects independent of weight loss or glycemic outcomes

Li J, Deng J, Sheng W, Zuo Z

(3) GDF8 and ActA blocking antibodies on their own (-MSTN/-ActA)

Ferreira JP, Sharma A, Butler J, Packer M, Zannad F, Vasques-Nvoa F et al (2023) Glucagon-like peptide-1 receptor agonists across the spectrum of heart failure