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Self-paying customers historically had to fork out nearly $1000 per month for injectable GLP-1 drugs, although Novo Nordisk slashed this price at the end of last year

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Over the last few years, several regulatory authorities, such as the FDA and EMA, reported the incidence of mood alterations, depressive symptoms, and even suicidal thoughts with the use of GLP-1 receptor agonists during the pharmacovigilance surveillance process, which raises the issue of their psychiatric safety [13,14,15]

plantarum activates toll-like receptors (TLRs) signaling, leading to the translocation of the pivotal structural protein Zonula occludens-1 (ZO-1) to the tight junction domain in intestinal models (165)