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It is crucial to note that in most CVOTs the primary endpoint was a composite endpoint of major adverse cardiovascular events (MACE), with HF hospitalisation typically a prespecified secondary or exploratory outcome

Weight loss is associated with increased NAD(+)/SIRT1 expression but reduced PARP activity in white adipose tissue

Wadden TA, Berkowitz RI, Womble LG, Sarwer DB, Phelan S, Cato RK, et al
PMC 5050443

Gardner J
