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Semaglutide dosing follows a gradual titration schedule starting at 0.25 mg weekly, with increases every four weeks to reach therapeutic levels

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GLP-1 medications may increase kidney stone risk through dehydration and uric acid changes, but individual risk depends on baseline kidney function, hydration status, and metabolic factors

Lifestyle interventions remain the cornerstone of obesity management in older adults, with emphasis on resistance training for muscle strength and bone mineral density preservation