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Many of these studies are from large databases, which are powerful tools in elucidating patterns on a population level, but can also be misleading due to their immense statistical power

Notably, the STEP TEENS trial showed that semaglutide 2.4 mg, administered once weekly via subcutaneous injection, can be used in individuals aged 12 years and older, as adolescents with obesity treated with semaglutide experienced a significant reduction in BMI compared with placebo, along with improvements in several cardiometabolic risk factors [47]

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These findings highlight that psychiatric comorbidity is not uncommon among surgical candidates, and that BD in itself should not be viewed as an exclusion criterion