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Reduction of Heart Failure About half of people with heart failure have preserved ejection fraction (HFpEF), so rather than diminished pump function it is the impaired ability for the heart to relax and fill (diastolic dysfunction) that accounts for their symptoms

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Upon gastric distention, GLP-1 signals are relayed via vagal nerves to the ventromedial nucleus tractus solitarius (NTS) in the brainstem