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A vicious cycle is therefore present between visceral adipose tissue excess, systemic insulin resistance, and testicular malfunctioning ( 4.5 Cancer Based on the International Agency for Research on Cancer (IARC), obesity is associated with an increased risk of many cancers such as colorectal, kidney, esophagus, endometrium, breast, pancreas, thyroid, liver, ovary, gallbladder, and prostate cancer

*Ozempic and Wegovy also have FDA-approved cardiovascular benefits for certain patients

Because Retatrutide is still investigational, long-term safety especially outside controlled trials remains less certain

Metrics to track Beyond weight, track these metrics weekly or biweekly: Waist circumference at the navel, first thing in the morning Hip circumference at the widest point Energy level on a 1 to 10 scale Sleep quality on a 1 to 10 scale Appetite level on a 1 to 10 scale Side effects type and severity Exercise type and duration Request blood work from your provider at baseline, 12 weeks, and 24 weeks at minimum

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