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Pool of Seven Controlled Clinical Trials Adverse reactions were also evaluated in a larger pool of adult patients with type 2 diabetes mellitus participating in seven controlled clinical trials which included two placebo-controlled trials (SURPASS-1 and -5), three trials of MOUNJARO in combination with metformin, sulfonylureas, and/or SGLT2 Inhibitors (SURPASS-2, -3, -4) [see Clinical Studies (14.3)] and two additional trials conducted in Japan

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The standard escalation protocol Your healthcare provider will typically increase your dose by 2.5 mg every 4 weeks, following this progression: Week 14: 2.5 mg Week 58: 5 mg Week 912: 7.5 mg Week 1316: 10 mg Week 1720: 12.5 mg Week 21+: 15 mg (maximum dose) Four weeks is the minimum time at each dose, but it is not a fixed deadline

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Weight loss continues progressively over many months, with peak effects generally observed between 36 and 72 weeks of treatment

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