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Reprod Sci (2021) 28(10):27708

Pipeline and Technology Innovation Analysis GLP-1 Weight Loss Drug Market Pipeline: Triple Agonists, Oral Formulations, and Amylin Combinations Define the 20262035 Innovation Frontier Key GLP-1 Pipeline Molecules, Mechanisms, Development Stage, and Peak Sales Projections Triple agonist therapies targeting GLP-1, GIP, and glucagon receptors simultaneously represent the most significant efficacy advance in obesity pharmacotherapy since semaglutide

Natriuresis Acute infusion of GLP-1 has been shown to stimulate diuresis and natriuresis in both experimental (Skov et al., 2013

The hepatic benefits of GLP-1RAs are partially independent of weight loss, as demonstrated in clinical trials in which matched weight loss achieved by lifestyle intervention did not replicate the full metabolic improvements seen with GLP-1RA therapy, including enhanced glucose handling and decreased de novo lipogenesis (20)

Despite their therapeutic efficacy, they are associated with metabolic side effects, most significantly steroid-induced hyperglycaemia (SIH) and steroid-induced diabetes (SID)