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GLP-1 receptor agonists enhance insulin secretion, suppress glucagon, slow gastric emptying, and promote satiety through central pathways

But increased demand may increase prices when they are more widely available

A majority of pancreatic cancer cases go undetected until the cancer worsens

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Even with careful engineering of receptor balance, potency and pharmacokinetics, problems may still crop up, as illustrated by SAR425899s unexpected development failure due to excessive gastrointestinal adverse events during its Phase 2 trials