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The SURMOUNT and SURPASS clinical trials did not identify insomnia as a statistically significant adverse event compared to placebo

The phentermine and tirzepatide combination and phentermine and semaglutide combination are increasingly common in clinical practice, though this represents off-label use
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In clinical trials, gastrointestinal adverse events occurred in approximately 39% of patients at the 5 mg dose and 46% at 10 mg