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As reported at the 2026 Crohns and Colitis Congress, GLP-1 RAs are potentially beneficial as an adjunct to Crohns disease management for patients with overweight or obesity.

Evidence-based comparison of ecnoglutide (cAMP-biased GLP-1 agonist) and semaglutide (selective GLP-1 agonist), including SLIMMER Phase 3, STEP, and SELECT trial data.

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Semaglutide is marketed as Ozempic for type 2 diabetics and Wegovy for obesity treatment.

These receptors are activated when peptide ligands interact with extracellular receptor domains, producing conformational changes that initiate intracellular signaling