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Gehart H, van Es JH, Hamer K, Beumer J, Kretzschmar K, Dekkers JF, et al
Who is most at risk of vitamin B12 deficiency whilst taking retatrutide

The observations in SUSTAIN-6 are predictable, given that intensified versus conventional insulin therapy is well known to have the capacity to precipitate initial worsening of retinopathy in patients with T2D with advanced preexisting retinopathy, as shown in the Diabetes Control and Complications Trial (82)

10.1152/ajpendo.00521.2024 [DOI] [PMC free article] [PubMed] [Google Scholar] 71.Iepsen EW, Lundgren JR, Hartmann B et al (2015) GLP-1 receptor agonist treatment increases bone formation and prevents bone loss in weight-reduced obese women

Interestingly, even in obese swine, GLP-1R activation can improve cardiac function and augment cardiac output after MI [75]
