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The caloric impact of moving less, combined with the metabolic slowdown from weight loss, creates a double deficit that easily produces weight gain

Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients with Chronic Heart Failure and Reduced Ejection Fraction

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Martha Viera, MD References National Library of Medicine, 2024, Glucagon-Like Peptide-1 Receptor Agonists Sofwave, Lost Weight, Gained Loose Skin or Muscle Loss

This weight loss itself further improves insulin sensitivity and metabolic health