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We found that tirzepatide is superior in reducing HbA 1c compared with other injectable therapies, in particular basal insulin and once-weekly GLP-1 RAs

However, in contrast to anti-hyperlycemic agents such as metformin, pioglitazone and peroxisome proliferator-activated receptor gamma (PPAR) agonists, which were particularly well studied in this matter, very few clinical studies concerning the effects of GLP-1R targeting therapeutics on alleviation of depressive symptoms in humans have been carried out so far [118, 119]

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Earlier studies have shown that oral Wegovy results in an average of 16.6% weight loss, while Foundayo showed 12.4% on average among patients who stayed on the treatment

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