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While challenges with adherence, side effects, and weight regain upon discontinuation have prompted the search for additional strategies, targets like GLP-1R, GIPR, and GDF8 (Myostatin) still remain the most highly relevant and active areas of research for developing effective obesity treatments

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Weight Loss Efficacy (Phase 2, 48 Weeks) * Retatrutide: Mean body weight reduction up to 24.2% * Eloralintide: Mean body weight reduction up to 20.1% Both agents place themselves among the most potent obesity therapies currently in clinical development.