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Pulsatile tinnitus (PT) is a complex otologic condition often linked to idiopathic intracranial hypertension (IIH), vascular abnormalities, and obesity, with emerging treatments focusing on glucagon-like peptide-1 (GLP-1) receptor agonists

The hypothesis posits that a systems-based review of GLP-1 RA mechanisms will reveal positive and negative effects across multiple organ systems, providing comprehensive insights into the hormone's physiological impact.This systematic review will assess the appropriateness of GLP-1 RAs in various aforementioned patient health states, shedding light on their potential impacts on comorbidities

Another key regulator of insulin signaling is the Ser/Thr kinase G protein-coupled receptor kinase 2 (GRK2)

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