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doi: 10.1016/j.copbio.2020.08.009
10.1016/s0140-6736(22)01655-5 2 AhmannA.RodbardH
In autoimmune patients, similar activation of Tregs with low dose IL-2 results in only transient activation of IL-2R signaling due to a defect in the inhibition of IL-2R desensitization, resulting in reduced pSTAT5 and DEPTOR degradation and loss of the Treg phenotype ( Figure 4 )
These studies found tirzepatide lowered AHI in participants
