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FDA approves new drug treatment for chronic weight management, first since 2014
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2022 Jul 6;10:950623
Exendin 939 directly binds to the TRPV1 channel To assess the direct interaction between exendin 939 and the TRPV1 channel, we conducted a protein binding assay using His-tagged exendin 939, which was able to pull down the TRPV1 channel (Fig
Conversely, the chronic exposure to the GLP-1RA Exendin-4 (Ex4) reduced the hypothalamic expression of the kisspetptin-1 (Kiss-1) receptors, with a marked reduction of the preovulatory LH peak and a delayed puberty onset [35]
