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Comparative Effectiveness of Dapagliflozin vs DPP-4 Inhibitors on a Composite Endpoint of HbA1c, Body Weight and Blood Pressure Reduction in the Real World

The interview schedule was developed through discussion with healthcare professionals including a clinician working in a tier 3 obesity service, a diabetes physician, and a psychiatrist specialising in diabetes and mental health, as well as a member of the public with lived experience of taking a GLP-1 receptor agonist (see supplementary material p3)

Improved Metabolic Markers The combination may support better blood sugar control,improved insulin sensitivity, and a lower long-term risk of metabolic syndrome.Preserving lean mass during weight loss also helps maintain a higher restingmetabolic rate, which supports long-term weight management

These therapeutic strategies underscore the necessity of treating the person as a whole, rather than focusing on separate symptomatology