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How do you think therapies like Retatrutide will reshape obesity and metabolic care in the next few years

Inhibition of food intake by hypothalamic PPAR activation is, however, not undisputed since hypothalamic viral-mediated overexpression of PPAR, or third ventricle administration of the PPAR agonist Rosiglitazone, has also been shown to increase food intake and body weight in rats 7
Most guidance suggests you aim to consume 200300 calories below your TDEE for weight loss

Starting at 0.25 mg, your dose may increase to 0.5 mg in week four, then 1.0 mg in week eight, depending on clinical judgment and your individual response

Hnninen, T