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Peptide therapeutics are particularly well suited to this paradigm, as their endogenous nature often allows direct linkage between receptor engagement and downstream physiological effects
2014;11(5): e1001647
Hypoglycemia is a potential adverse effect though this is rare given the glucose-dependent mechanism and is usually seen in patients taking insulin or insulin secretagogues [47]
In clinical trials, Semaglutide GLP-1 was studied for up to 16 months for weight management
Stapleton F, Alves M, Bunya VY, et al
