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The patent was invalidated the next year, but Novo appealed the decision, and the patent office has yet to make a final determination
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However, in most cases, the glucose-sensing element and the drug-releasing module are integrated into the same formulation 21,22,23
The response to 10 mmol/l alanine was much stronger than that to glutamine, and was too large to measure accurately due to saturation of the fura-2
