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And the cold temperature makes it easier to eat than hot food, which many semaglutide users find more tolerable during the adjustment period

The pivotal SURPASS clinical trial programme, which evaluated the efficacy and safety of tirzepatide in thousands of patients with type 2 diabetes, did not identify RLS or restless leg symptoms as a recognised adverse effect

Eli Lilly, which also makes the weight loss drugs Mounjaro and Zepbound, said it plans to complete seven additional phase 3 clinical trials of retatrutide in 2026, compiling data that will be submitted to the U.S

doi: 10.1523/JNEUROSCI.2105-10.2010, 140 SticeE.YokumS.BohonC.MartiN.SmolenA