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Description
GLP-1 medications show substantial benefit
Cardiometabolic Health
[DOI] [PMC free article] [PubMed] [Google Scholar] 61
2012;2:e51e51
The product information available through the EMA states that the visceral abnormalities and major skeletal malformations seen after maternal exposure to semaglutide are probably due to embryotoxicity caused by a GLP-1 receptor-mediated impairment of the nutrient supply across the rat yolk sac, which has unclear translational significance for humans due to a difference in yolk sac anatomy
