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Anecdotally, patients in these situations report fewer disruptions and a smoother adjustment period

A Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) enrolled 338 adults with obesity and reported mean body weight reductions of up to approximately 24% over 48 weeks at the highest dose studied (12 mg weekly)

Here is how the major options compare: Of these, only Wegovy, Saxenda, and a small number of newer agents are specifically approved for weight management

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