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No Cold Chain: Because they are chemically stable, they dont require the expensive refrigerated shipping and storage that injectables do

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Gastrointestinal side effects are a little more common in the oral version than in the injectables

Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

Similarly, the specific blocking of Gq signalling with YM254890 or transient receptor potential melastatin 5 (TRPM5) with triphenylphosphine oxide (TPPO) suppressed the triagonist-induced enhancement of GSIS