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Last year, the share of apparel exchanges in which shoppers traded down to a smaller size hit 14.6 percent, the third straight year it climbed, according to a review by returns-software firm Narvar of 38 retailers.

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This incretin hormone plays several crucial roles in metabolic health: Stimulates insulin secretion from the pancreas in a glucose-dependent manner Suppresses glucagon release (which helps prevent blood sugar spikes) Slows gastric emptying, promoting longer feelings of fullness Reduces appetite by acting on brain centers that control hunger Improves beta-cell function in the pancreas The natural GLP-1 hormone has a very short half-life (12 minutes) in the bloodstream because it is rapidly broken down by an enzyme called dipeptidyl peptidase-4 (DPP-4)