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Retatrutide, a GIP, GLP-1, and glucagon receptor agonist, for patients with type 2 diabetes and obesity (TRIUMPH-2): a randomised, double-blind, placebo-controlled, phase 3 trial
This finding suggests that DPP4 inhibitors, owing to their GLP-1-enhancing actions, may have a direct beneficial effect on cardiomyocyte function
Athletes might face additional side effects relating to sport performance
Rubino et al., Diabetes, Obesity and Metabolism 2025 meta-analysis of GI tolerability across SURMOUNT-1 to -4
The receptor is a class B GPCR that signals primarily through the Gs-adenylyl cyclase-PKA pathway
