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Description
PIONEER 2 included patients only receiving metformin, while PIONEER 3 included patients receiving metformin with or without sulfonylurea and PIONEER 4 included patients receiving metformin with or without an SGLT-2 inhibitor
None of these represents approved indications or established human pharmacology
References 1.Zhang L., Cai N., Mo L., Tian X., Liu H., Yu B
Key Takeaways Melatonin has clinically relevant interactions with several common medication classes that can affect either drug effectiveness or safety
Starting at lower doses and increasing slowly helps manage side effects for both medications
