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Thrombocytopenia and infections

These symptoms may indicate complications requiring immediate medical evaluation and potential treatment modification or discontinuation

they are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or MEN 2

Since vagal tone is involved in inflammatory responses and pain modulation, excessive stimulation or dysregulation of this pathway may contribute to heightened pain perception

These alterations affect brain activity through vagal pathways, inflammatory signaling, and microbial metabolites (such as GABA derivatives and short-chain fatty acids)