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The clearest hypothesis is that GSH synthesis is required for liver function

[PMC free article: PMC10002162] [PubMed: 36900932] (23 year old Polish man developed fatigue and jaundice approximately 3 months after starting ashwagandha [bilirubin 11.5 rising to 28.1 mg/dL, ALT 490 U/L, Alk P 227 U/L, INR 1.24], resolving within 3.5 months of stopping)

A steady state was achieved after the first dose of ALTUVIIIO

GHK-Cu delivers copper as a cofactor for this enzyme, ensuring that the collagen synthesis it stimulates produces properly crosslinked, stable tissue architecture

doi: 10.1080/19490976.2023.2178794 574 ZhaoFTieNKwokLYMaTWangJManDet al