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For this reason, MEL and its metabolites may serve as effective therapeutic agents in iron-induced oxidative stress, for example, in patients with Parkinsons and Alzheimers disease, in whom higher levels of iron and lipid peroxidation have been observed in the brain compared to healthy individuals [76,77]

[DOI] [PubMed] [Google Scholar] 308.Luo J., He W., Li X., Ji X., Liu J

[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Ndagijimana M., Laghi L., Vitali B., Placucci G., Brigidi P., Guerzoni E

On the other hand, MTI-101 is a promising CD44-binding peptidomimetic (a cyclized peptidomimetic derivative of HYD1) that induces necroptosis in MM cells through mechanisms involving oxidative stress, mitochondrial dysfunction, and necroptosis-like signaling, demonstrating efficacy even within the bone marrow microenvironment (30)

Simultaneous quantitation of kavalactones in kava dry extracts: Comparison of multi-standards and single standard validation approaches
