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In the STEP 1 trial (Wilding et al., New England Journal of Medicine, 2021
Given IGF-1 LR3's sensitivity and the significant investment involved, verification provides important assurance
An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R
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