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Chouchani E.T

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In contrast to other opioids like morphine, mitragynine and 7-hydroxymitragynine selectively activate the G-protein second messenger upon binding to the G-proteincoupled receptor rather than the -arrestin-2 signaling pathway, which is responsible for many of the adverse effects associated with typical opioids

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2 Therapeutic effects of clemastine in animal models and potential molecular mechanisms Since being identified for potential repurposing, clemastine has been administered in various animal models associated with demyelination (Figure 1A)