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Description
The apyrimidinic endonuclease/redox effector factor (APE1) is an important enzyme for DNA-damaged base removal, and decreased APE1 levels in sensory neurons increase neurotoxicity in OIPN models, targeting APE1 by the small molecules APX3330 and APX2009

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This stretch of residues includes a Gly-Pro-Gly motif with the G324 displaying the maximal C deviation of 2.4 , allowing the F325 (C shift of 1.6 ) to facilitate edge-to-face aromatic interactions with DA, which are absent in the NE-bound structure (Fig

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Hsiao et al
