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Pathways implicated in addiction also contribute to pathological overeating and obesity, they write
Its understanding who will see improvements in blood sugar, heart health, liver disease and kidney function. Long-term questions still remain Hardaway says GLP-1 drugs are essentially supercharged versions of a naturally occurring hormone, and decades of neuroscience research show that receptors can adapt to prolonged stimulation

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No major trials have tested GLP-1s in healthy people with a normal or low BMI, so its unclear how much weight such people might lose on the drug
